Drug Interaction Checker

drug interaction checker

Drug Interaction Checker

Dr. Rao Khurram Ayoub

Medically reviewed by Dr. Rao Khurram Ayoub, RPh, PhD (Pharmaceutics)

Written by Dr. Muhammad Imran, M.Phil, PharmD, BSc

Updated on

Medically written by: Muhammad Imran (Rph), Clinical Pharmacist
Medically reviewed by: Dr Rao Khurram Ayoub (PhD, M.Phil, Pharm.D), Deputy Director DTL Multan, Pakistan
Last reviewed: 21 June 2026
FDA DATA LIVE
Medication Safety

Drug Interaction Checker

Check for dangerous combinations — free, instant, and sourced directly from official FDA drug labels via openFDA.

Enter Your Medications

 U.S. FDA / openFDA
🔍
Add at least 2 drugs
Querying FDA drug label database…
⚠️ Something went wrong. Please try again.
Critical Contraindicated — avoid combination
Major Serious risk — use alternative
Moderate Monitor closely with doctor
Minor Low risk — be aware
⚕️
Medical Disclaimer: This tool is for educational purposes only and does not constitute medical advice. FDA drug labels may not reflect all known interactions. Always consult your pharmacist or physician before making any medication decisions. Data sourced from the U.S. Food & Drug Administration openFDA API (drug/label endpoint). Reviewed by Dr. Muhammad Imran, Pharm.D (Rxpedia.org).
WHO Rational Use Polypharmacy DDI Visual - RxPedia
WHO/ INRU RATIONAL • LIVE DATA

WHO says: 2 meds per encounter.
Polypharmacy = 5+ meds = DDI surge.

Rational drug use and adherence to national essential medicines lists reduces inappropriate polypharmacy and DDI risk — WHO.

2

WHO IDEAL

Avg drugs per prescription contact

5+

POLYPHARMACY

DDI risk jumps sharply

LIVE RISK METER

Average drugs / Rx WHO 2.0
12 Ideal3-4 Caution5+ High Risk
!

Each extra drug beyond 2 adds exponential interaction checks — especially antidiabetics + CV drugs.

>½
RESOURCE-LIMITED

DDI PREVALENCE WHO/INRUD STUDY

>50% of prescriptions had ≥1 potential DDI

More than half contained at least one potential drug-drug interaction using WHO/INRUD indicators — Pakistan tertiary hospital data.

Atif et al., 2026 • BMC HSR

MOST COMMON DDI CLUSTERS

Antidiabetics ×
Cardiovascular & Fluoroquinolones

A+B

Antidiabetic + Cardiovascular

e.g., metformin + ACE-I, SGLT2 + diuretics — hypoK, lactic risk

A+F

Antidiabetic + Fluoroquinolones

FQ dysglycemia — ↑ hypo/hyperglycemia risk with sulfonylureas

WHO/INRUD INDICATORS High Alert Pairs

WHO SOLUTION — RATIONAL USE

Rational Drug Use + Essential Medicines List = Fewer DDIs

WHO emphasizes rational prescribing and strict adherence to national essential medicines lists to curb inappropriate polypharmacy and DDI risk.

✓Average ≤2 drugs per encounter
✓Use EML — avoid non-essential combos
✓Check DDI before adding 5th drug
Read Full Study BMC Health Serv →

Citation: Atif, M., et al. (2026). Antidiabetic prescribing patterns, quality, and economic influence in resource-limited settings: evidence from a Pakistani tertiary care hospital using WHO/INRUD indicators. BMC Health Services Research. https://doi.org/10.1186/s12913-025-13783-6
WHO Guidance: WHO recommends average of two medications per prescription contact; polypharmacy (≥5 meds) significantly increases DDI risk. Emphasizes rational drug use and EML adherence.

WHO/INRUD Validated
i

How to use on RxPedia: Paste this card above DDI checker or antidiabetic reviews. Encourages checking Drug Interaction Checker before 5th drug added. Visual risk meter turns red at polypharmacy threshold.

Found a potential interaction? Get a deeper clinical breakdown including dosage, efficacy, and safety comparisons in our evidence-based medication and supplement reviews .

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